U2, actor-filmmaker George Clooney, singers Gladys Knight and Amy Grant, and composer-conductor Tania León will be saluted for their achievements in the arts at the 45th annual Kennedy Center Honors on Dec. 4 at the national arts center.

The Sunday night performance is the centerpiece of a weekend that includes a private dinner when the distinctive rainbow medals are presented and a fundraising gala for thousands following the Opera House show. The production, with its top-secret lineup of guests, will be broadcast later on CBS.

The 2022 honorees represent the best of the entertainment world, said Kennedy Center President Deborah Rutter, but they have also used their talents to inspire change.

“In each case, these are artists who are doing more than being performers. They are artists as citizens who are giving back and making the world a better place through art,” Rutter said, citing the philanthropic, humanitarian and educational contributions made by each. “It’s about art for life’s sake. These artists are a mirror to who we are.”